Default mode network functional and structural connectivity after traumatic brain injury

Default mode network functional and structural connectivity after traumatic brain injury.

Traumatic brain injury often results in cognitive impairments that limit recovery. The underlying pathophysiology of these impairments is uncertain, which restricts clinical assessment and management. Here, we use magnetic resonance imaging to test the hypotheses that: (i) traumatic brain injury results in abnormalities of functional connectivity within key cognitive networks; (ii) these change...

Default mode network connectivity predicts sustained attention deficits after traumatic brain injury.

Traumatic brain injury (TBI) frequently produces impairments of attention in humans. These can result in a failure to maintain consistent goal-directed behavior. A predominantly right-lateralized frontoparietal network is often engaged during attentionally demanding tasks. However, lapses of attention have also been associated with increases in activation within the default mode network (DMN). ...

The effects of task context and brain injury on default mode network brain functional connectivity

INRODUCTION The default mode network (DMN) has been a major area of research in recent years. Studies have sought to determine the exact nature of its activity and how these profiles of neural activity respond to cognitive demands or are abnormal in pathological conditions [e.g. 1-3]. Activity within the network has been correlated with rest and anti-correlated with task performance [4]. As suc...

Salience Network and Default Mode Network dysfunction after traumatic brain injury

Abnormal Brain Default-Mode Network Functional Connectivity in Drug Addicts

BACKGROUND The default mode network (DMN) is a set of brain regions that exhibit synchronized low frequency oscillations at resting-state, and is believed to be relevant to attention and self-monitoring. As the anterior cingulate cortex and hippocampus are impaired in drug addiction and meanwhile are parts of the DMN, the present study examined addiction-related alteration of functional connect...